FaSTR DNA from STRmix is an expert forensic software that rapidly analyzes DNA profiles and can assign a Number of Contributors (NoC) estimate..FaSTR DNA expedites the analysis of raw data generated by genetic analyzers and standard profiling kits. It does this by combining an intuitive, user-friendly graphical interface with easily understandable and laboratory-customizable rules.
FaSTR DNA also implements the optional use of artificial neural networks (ANN) for peak classification independent of, and in parallel to, the forensic analyst.
FaSTR DNA works by applying a set of fully configurable rules to analyze most DNA profiles automatically. In some instances, DNA analysis is more complex and automated heuristics (analysis rules) alone may not be able to resolve all profiles. Where the intervention of a DNA analyst is required, FaSTR DNA readily provides all details related to possible ambiguity of a peak (i.e. stutter type, stutter ratio, composite stutter, pull-up proportion, N/shoulder peak, peak morphology, low homozygote, heterozygote imbalance) and signals a requirement for the DNA analyst to make a decision. It then records and highlights changes made by the analyst.
Some new features in this version of FaSTR DNA include: control genotype concordance checking; improved ladder quality assessment; the detection and filtering/flagging of composite stutters using allele-specific stutter ratios; and the ability to customize stochastic homozygote thresholds per dye color.
The algorithms used for analysis in FaSTR DNA are conceptually adapted from the proven approach of OSIRIS DNA (National Center for Biotechnology Information).
To see a brief overview of FaSTR DNA, visit https://vimeo.com/423795087/16f82f22b1. For more information on FaSTR DNA, visit https://www.strmix.com/fastr.
